Generic alternatives and generic equivalents to brand-name medications may help patients save money. The U.S. Food and Drug Administration (FDA) states that it ensures the safety and effectiveness of the generic drugs it approves.1 According to the FDA, a generic drug is identical, or bioequivalent, to a brand-name drug and is "required to have the same active ingredient, strength, dosage form and route of administration as the brand-name product."2

A generic alternative is not a direct generic for a particular branded medication, but in most cases it is in the same therapeutic class as the brand. Alternative drugs produce similar clinical outcomes and often have similar side-effect profiles.

Generic drug options

Please refer to the chart below for a list of common brand drugs and corresponding generic and over-the-counter (OTC) alternatives. When a generic equivalent to a brand is listed below, this format is used: name of equivalent generic followed by brand name in parentheses [e.g., benazepril (Lotensin)]. You can also download a printable version of the Humana generic drug guide. , PDF opens new window

Humana generic drug guide 

Therapeutic class Brand products Generic and over-the-counter (OTC) alternatives

Angiotensin-converting enzyme (ACE) inhibitors

Accupril, Aceon, Altace, Capoten, Lotensin, Mavik, Monopril, Prinivil, Univasc, Vasotec, Zestril

benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), trandolapril (Mavik)

Angiotensin II receptor blockers (ARBs)

Atacand, Avapro, Benicar, Cozaar, Diovan, Edarbi, Hyzaar, Micardis, Teveten

candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), telmisartan (Micardis), valsartan (Diovan)

Angiotensin II receptor antagonist/combinations

Atacand HCT, Avalide, Benicar HCT, Diovan HCT, Exforge, Exforge HCT, Micardis HCT, Teveten HCT

candesartan/HCTZ (Atacand HCT), eprosartan/HCTZ (Teveten HCT), irbesartan/HCTZ (Avalide), losartan/ HCTZ (Hyzaar), telmisartan/HCTZ (Micardis HCT), valsartan/amlodipine (Exforge), valsartan/amlodipine/HCTZ (Exforge HCT), valsartan/HCTZ (Diovan HCT)

Antibiotics

Augmentin, Augmentin ES, Augmentin XR, Avelox, Cipro, Levaquin, Zithromax

amoxicillin/clavulanate (Augmentin, Augmentin ES, Augmentin XR), azithromycin (Zithromax), ciprofloxacin (Cipro), levofloxacin (Levaquin), moxifloxacin (Avelox)

Anticoagulants

Arixtra, Coumadin, Eliquis, Jantoven, Lovenox, Pradaxa, Savaysa, Xarelto

enoxaparin injection (Lovenox), fondaparinux injection (Arixtra), warfarin (Coumadin, Jantoven)

Antidepressants

Celexa, Cymbalta, Effexor XR, Fetzima, Irenka, Khedezla, Lexapro, Marplan, Paxil, Paxil CR, Pristiq, Prozac, Sarafem, Savella, Wellbutrin, Wellbutrin XL, Viibryd

bupropion (Wellbutrin), bupropion XL (Wellbutrin XL), citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), fluvoxamine CR (Luvox CR), nefazodone (Serzone), paroxetine (Paxil), paroxetine CR (Paxil CR), sertraline (Zoloft), venlafaxine (Effexor), venlafaxine XR (Effexor XR)

Antiemetic agents

Anzemet, Compro, Emend, Kytril, Reglan, Tigan, Zofran, Zofran ODT, Zuplenz

granisetron (Kytril), metoclopramide (Reglan), ondansetron (Zofran, Zofran ODT, Zuplenz), prochlorperazine (Compro), trimethobenzamide (Tigan)

Antiepileptic drugs

Aptiom, Banzel, Carbatrol, Depakote, Depakote ER, Diamox, Epitol, Felbatol, Fycompa, Gabitril, Keppra, Keppra XR, Lamictal, Lamictal XR, Lyrica, Neurontin, Oxtellar XR, Potiga, Sabril, Qudexy XR, Tegretol, Topamax, Trileptal, Trokendi XR, Vimpat, Zonegran

acetazolamide (Diamox), carbamazepine (Carbatrol, Epitol, Tegretol, Tegretol XR), divalproex (Depakote), divalproex extended release (Depakote ER), felbamate (Felbatol), gabapentin (Neurontin), lamotrigine (Lamictal), lamotrigine ER (Lamictal XR), levetiracetam (Keppra), levetiracetam extended-release (Keppra XR), oxcarbazepine (Trileptal), tiagabine (Gabitril), topiramate (Topamax), valproic acid (Depakote), zonisamide (Zonegran)

Antifungals

Ancobon, Diflucan, Grifulvin V, Gris- Peg, Lamisil, Nizoral, Terbinex, VFend

fluconazole (Diflucan), flucytosine (Ancobon), griseofulvin (Grifulvin V, Gris-Peg), ketoconazole (Nizoral), nystatin (Mycostatin, Nystop), terbinafine (Lamisil), voriconazole (VFend)

Antiglaucoma agents

Azopt, Betagan, Betimol, Cosopt, Istalol, Lumigan, Ocupress, Rescula, Timoptic, Travatan, Travatan Z, Trusopt, Xalatan, Zioptan

betaxolol (Betoptic), bimatoprost (Lumigan), carteolol (Ocupress), dorzolamide (Trusopt), dorzolamide/timolol (Cosospt), latanoprost (Xalatan), levobunolol (Betagan), metipranolol (OptiPranolol), timolol (Betimol, Istalol, Timoptic), travoprost (Travatan)

Antihistamines

Allegra OTC, Allegra-D OTC, Clarinex, Clarinex-D, Claritin OTC, Claritin-D OTC, Xyzal, Zyrtec OTC, Zyrtec-D OTC

desloratadine (Clarinex), fexofenadine OTC (Allegra OTC), fexofenadine/ pseudoephedrine (Allegra-D OTC), levocetirizine (Xyzal), loratadine OTC (Claritin OTC), loratadine/pseudoephedrine OTC (Claritin-D OTC), cetirizine OTC (Zyrtec OTC), cetirizine/ pseudoephedrine OTC (Zyrtec-D OTC)

Antimigraine agents

Alsuma, Amerge, Axert, Frova, Imitrex, Maxalt, Relpax, Sumavel, Treximet, Zomig

almotriptan (Axert), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), zolmitriptan (Zomig)

Antiplatelet

Aggrenox, Brilinta, Effient, Plavix

clopidogrel (Plavix), dipyridamole/aspirin (Aggrenox), ticlopidine (Ticlid)

Antiparkinsonian agents

Apokyn, Azilect, Comtan, Eldepryl, Neupro, Mirapex, Parlodel, Requip, Requip XL, Stalevo, Tasmar

benztropine* (Cogentin), bromocriptine (Parlodel, Cycloset), cabergoline (Dostinex), entacapone (Comtan), pramipexole (Mirapex), ropinirole (Requip), ropinirole extended release (Requip XL), tolcapone (Tasmar), trihexyphenidyl* (Artane)

Antiretrovirals

Combivir, Emtriva, Epivir, Epzicom, Retrovir, Trizivir, Videx, Viramune, Zerit, Ziagen

abacavir (Ziagen), abacavir/lamivudine/zidovudine (Trizivir), didanosine (Videx), lamivudine (Epivir), lamivudine/zidovudine (Combivir), nevirapine (Viramune), stavudine (Zerit), zidovudine (Retrovir)

Antispasmodics

Detrol, Detrol LA, Ditropan, Ditropan XL, Enablex, Gelnique, Myrbetriq, Oxytrol, Pamine, Sanctura, Sanctura XR, Toviaz, Vesicare

flavoxate (Urispas), oxybutynin (Ditropan), oxybutynin ER* (Ditropan XL), tolterodine (Detrol), tolterodine ER (Detrol LA), trospium (Sanctura)

Antivirals

Copegus, Cytovene, Famvir, Flumadine, Sitavig, Valcyte, Valtrex, Zovirax

acyclovir (Zovirax), famciclovir (Famvir), ganciclovir (Cytovene), ribavirin (Copegus), rimantadine (Flumadine), valacyclovir (Valtrex), valganciclovir (Valcyte)

Benign prostatic hyperplasia (BPH) agents

Avodart, Cardura*, Cardura XL*, Flomax, Hytrin*, Jalyn, Proscar, Rapaflo, Uroxatral

alfuzosin SR (Uroxatral), doxazosin* (Cardura), finasteride (Proscar), tamsulosin (Flomax), terazosin* (Hytrin)

Beta blockers

Bystolic, Coreg, Coreg CR, Inderal LA, Lopressor, Tenoretic, Tenormin, ToprolXL, Zebeta, Ziac

atenolol (Tenormin), atenolol/chlorthalidone (Tenoretic), bisoprolol (Zebeta), bisoprolol/HCTZ (Ziac), carvedilol (Coreg, Coreg CR), metoprolol (Lopressor), metoprolol XL (Toprol-XL), propranolol LA (Inderal LA)

Bisphosphonates

Actonel, Atelvia, Boniva, Fosamax

alendronate (Fosamax), ibandronate (Boniva), risedronate (Actonel)

Calcium channel blockers

Adalat CC, Caduet, Calan, Cardene, DynaCirc CR, Lotrel, Norvasc, Sular, Plendil

amlodipine (Norvasc), amlodipine/benazepril (Lotrel), amlodipine/atorvastatin (Caduet), diltiazem (Cardizem, Cartia XT, Dilt-CD, Tiazac), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat CC), nisoldipine (Sular), verapamil (Calan)

Cholinesterase/N-methyl-D-aspartate (NMDA) inhibitors

Aricept, Exelon, Namenda, Razadyne, Razadyne ER

donepezil (Aricept), galantamine (Razadyne), galantamine ER (Razadyne ER), rivastigmine (Exelon)

Nasal corticosteroids

Beconase AQ, Flonase, Nasarel, Nasonex, Nasacort AQ, QNASL, Rhinocort Aqua, Veramyst, Zetonna

budesonide (Rhinocort Aqua), fluticasone (Flonase OTC), flunisolide (Nasarel), triamcinolone (Nasacort OTC)

Opioids

Abstral, Actiq, Avinza, Butrans, Demerol, Dilaudid, Dolophine, Duragesic, Embeda, Exalgo, Fentora, Hysingla ER, Ibudone, Kadian, MS Contin, Opana ER, Oramorph SR, Oxycontin, Reprexain, Subutex, Suboxone, Zohydro ER

buprenorphine (Buprenex, Subutex, Suboxone), butorphanol (Stadol), codeine sulfate, fentanyl transdermal patch (Duragesic), hydromorphone (Dilaudid), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine), morphine sulfate (Avinza), morphine sulfate ER (MS Contin/Oramorph SR), oxycodone (Oxycontin), oxymorphone ER (Opana ER), tramadol (Ultram)

Ophthalmic agents: antihistamine

Bepreve, Elestat, Emadine, Lastacaft, Naphcon, Optivar, Pataday, Patanol, Pazeo

azelastine (Optivar), epinastine (Elestat), ketotifen (Zaditor OTC), naphazoline (Naphcon)

Ophthalmic agents: antihistamine

Bepreve, Elestat, Emadine, Lastacaft, Naphcon, Optivar, Pataday, Patanol, Pazeo

azelastine (Optivar), epinastine (Elestat), ketotifen (Zaditor OTC), naphazoline (Naphcon)

Ophthalmic agents: NSAID

Acular, Acular LS, Acular PF, Acuvail, Bromday, Ilevro, Nevanac, Ocufen, Prolensa, Voltaren, Xibrom

bromfenac (Xibrom), diclofenac (Voltaren), flurbiprofen (Ocufen), ketorolac (Acular/LS/PF)

Proton pump inhibitors

Aciphex, Dexilant, Nexium, Prevacid, Prevacid SoluTab, Prilosec, Protonix, Zegerid

esomeprazole (Nexium OTC), lansoprazole (Prevacid OTC), omeprazole (Prilosec OTC), omeprazole/ sodium bicarbonate (Zegerid OTC), pantoprazole (Protonix), rabeprazole (Aciphex)

Sedative-hypnotics

Ambien, Ambien CR, Belsomra, Edluar, Intermezzo, Lunesta, Restoril, Rozerem, Silenor, Sonata

eszopiclone (Lunesta), temazepam (Restoril), trazodone (Desyrel), zaleplon (Sonata), zolpidem (Ambien), zolpidem CR (Ambien CR)

Statins

Crestor, Lescol, Lescol XL, Lipitor, Livalo, Mevacor, Pravachol, Vytorin, Zocor

atorvastatin (Lipitor), fluvastatin (Lescol, Lescol XL), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor)

Stimulants

Adderall, Adderall XR, Aptensio XR, Concerta, Daytrana, Focalin XR, Vyvanse, Zenzedi

dextroamphetamine salts extended-release (Adderall and Adderall XR), methylphenidate (Concerta)

*May not be appropriate for persons ages 65 years and older; † indicated for short-term use only.

Please note: The information provided here does not include an exhaustive list of drug contraindications or recommended restrictions and precautions for all patients.

Sources

  1. "Generic Drug Facts," US Food & Drug Administration, last accessed December 3, 2018, https://www.fda.gov/drugs/ resourcesforyou/consumers/buyingusingmedicinesafely/genericdrugs/ucm167991.htm. , opens new window
  2. "Generic Drug Facts."

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